Work

Brain aging and neurodegenerative diseases: physiological insights from anti-aging protein Klotho

Year: 2026

Type: article

Abstract: signaling, mitochondrial-redox homeostasis, neuroimmune balance, growth factor signaling, and barrier integrity. Consistent with these physiological roles, reduced Klotho availability is associated with cognitive decline and multiple neurodegenerative disorders. This review positions Klotho as a central determinant of cognitive reserve and neuro-resilience, providing a unifying physiological framework that links systemic homeostasis to brain aging and explains how disruption of Klotho signaling amplifies vulnerability to neurodegenerative disease, whereas its preservation supports lifelong brain integrity.

Source: Korean Journal of Physiology and Pharmacology

DOI: 10.4196/kjpp.26.015

Authors: Phuong Anh Do, Huu Son Nguyen, Seung-Kuy Cha

Institutions: Yonsei University, VinUniversity, Vinmec Research Institute of Stem Cell and Gene Technology

Language: English

Topic: Parathyroid Disorders and Treatments

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Ministry of Education, National Research Foundation of Korea, Ministry of Science and ICT, South Korea