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Sulbactam–durlobactam and cefiderocol combination treatment of Burkholderia cenocepacia -associated Fitz–Hugh–Curtis syndrome

Year: 2026
Type: article
Study design: Case Report
Abstract: ABSTRACT A 50-year-old woman with cystic fibrosis (CF) and lung transplantation developed persistent deep abscesses due to multidrug-resistant (MDR) Burkholderia cenocepacia, unresponsive to multiple antibiotics and surgeries. Combination therapy with sulbactam–durlobactam (SUL-DUR) and cefiderocol (FDC) along with surgical interventions led to clinical and radiographic stability. This report of a successful sulbactam–durlobactam and cefiderocol treatment highlights this targeted β-lactam-β-lactamase inhibitor combination as an option for refractory B. cepacia complex (BCC) infections.
DOI: 10.1128/aac.01542-25
Authors: Bhavita Gaglani, Tessa M. Andermann, Claire Wate, Jorge Oldan, Chirag S. Desai, Steven H. Marshall, Robert A. Bonomo, Ray Coakley, David van Duin, Anne Lachiewicz
Institutions: Wake Forest University Health Sciences, Wake Forest University, University of North Carolina at Chapel Hill, Louis Stokes Cleveland VA Medical Center, University Hospitals of Cleveland, University Hospitals Cleveland Medical Center, Case Western Reserve University
Language: English
Subfield: Epidemiology
Field: Medicine
Open Access status: diamond
OpenAlex ID: W7158965750
FWCI: 4.235
Cites: 19
Cited by: 1
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