Work

Error Traps in Pediatric Neuromuscular Block

Year: 2026

Type: article

Abstract: BACKGROUND: Neuromuscular blocking agents are essential for safe pediatric anesthesia but remain a frequent source of preventable morbidity when misused, inadequately monitored, or incompletely reversed. Children, particularly neonates and infants, are especially vulnerable to residual neuromuscular block due to developmental pharmacological variability and limited physiological reserve. AIMS: To describe common and preventable "error traps" in pediatric neuromuscular block management and to highlight strategies to improve safety across the perioperative continuum. METHODS: This narrative review synthesizes current evidence and clinical practice patterns to identify recurrent pitfalls in the use, monitoring, reversal, and postoperative management of neuromuscular blocking agents in children. RESULTS: Four major error traps were identified: omission of neuromuscular blocking agents when optimal intubating conditions are required; failure to use quantitative neuromuscular monitoring; inappropriate or mistimed pharmacological reversal; and failure to recognize and treat residual paralysis. These errors contribute to a persistently high incidence of residual neuromuscular block and are associated with increased risk of postoperative respiratory complications. Developmental pharmacokinetic and pharmacodynamic variability further amplifies these risks in pediatric populations. CONCLUSIONS: Avoidance of these error traps requires systematic application of evidence-based practices, including routine use of quantitative neuromuscular monitoring and objective confirmation of recovery with a train-of-four ratio ≥ 0.9 prior to extubation. Embedding these principles into clinical practice is essential to improving safety in pediatric anesthesia.

Source: Pediatric Anesthesia

DOI: 10.1002/pan.70202

Authors: Gabriel Soares de Sousa, Debra Faulk, Vinicius Caldeira Quintao, Niekoo Abbasian, Hans D. de Boer, Ricardo Vieira Carlos