Work

MC4R Antagonists: A Promising New Hope for the Treatment of Cachexia and Wasting Diseases

Year: 2026

Type: article

Abstract: Melanocortin-4 receptor (MC4R) is a key receptor in the hypothalamus regulating appetite and energy metabolism. Research has indicated that MC4R agonists have demonstrated potential for weight loss; its antagonists may stimulate appetite and weight gain, showing potential therapeutic applications in patients with anorexia or cachexia or those requiring weight restoration. However, the signaling mechanism, clinical applications, and safety profile of MC4R antagonists still require in-depth investigation. The purpose of this review is to comprehensively summarize the research progress of MC4R antagonists, analyze their mechanism of action and clinical applications, evaluate their safety profile, and explore future research directions. Future studies should focus on developing safer and more effective MC4R antagonists and exploring the therapeutic potential of MC4R in other diseases.

Source: Die Pharmazie

DOI: 10.31083/pharmazie51802

Authors: Jiajia Shi, Jiaying Xiong, Chao Hao, Ling Huang, Yin Chen

Institutions: Jiangsu Ocean University, Jiangsu Provincial Key Laboratory of Marine Bioresources and Environment, Guangxi University of Science and Technology

Language: English

Topic: Regulation of Appetite and Obesity

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7159165162

FWCI: 2.95

Cites: 78

Cited by: 1

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