Sleep and the brain : neurological insights into rest and cognition
Year: 2026
Type: article
Abstract: Sleep is a fundamental yet often overlooked biological process essential for maintaining optimal brain function, cognition, and physical recovery. This review synthesizes current evidence on the neurophysiological, cognitive, and restorative dimensions of sleep, with emphasis on its translational relevance for medical students, student athletes, clinicians, and patients. We explore the underlying neurological mechanisms governing sleep regulation, including circadian rhythms, neurotransmitter activity, and neural control systems such as the VLPO and orexin pathways. The cognitive implications of sleep are examined through its role in attention, learning, and memory consolidation, supported by theories like synaptic homeostasis and stage-dependent neuroplasticity. Furthermore, we analyse how sleep deprivation and disorders such as sleep apnoea detrimentally affect physical performance, emotional stability, and overall health. The physiological basis of muscle recovery during sleep and the consequences of inadequate rest on repair and endurance are also discussed. Finally, emerging innovations in sleep science, including wearable technologies, pharmacological aids, and neurotechnological research, are reviewed to highlight future directions and challenges. Collectively, this literature review underscores sleep as an active, restorative process vital for cognitive integrity, physical resilience, and long-term wellbeing.
Source: OAR@UM (University of Malta)
Authors: Mifsud, Andre, Cefai, John
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7159551532