Work

Ion Mobility-Mass Spectrometry and Collision Induced Unfolding Reveal Linker-Payload Effects on Antibody-Drug Conjugate Higher-Order Structure and Stability

Year: 2026

Type: article

Source: Bioconjugate Chemistry

DOI: 10.1021/acs.bioconjchem.6c00018

Authors: Devin M. Makey, Marion H. Emmert, Hang Hu, Eli J. Larson, Emmanuel Appiah-Amponsah, Erik L. Regalado, Rodell C. Barrientos, Brandon T. Ruotolo

Institutions: Merck & Co., Inc., Rahway, NJ, USA (United States), University of Michigan

Language: English

Topic: Mass Spectrometry Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: Merck, National Institutes of Health, National Institute of General Medical Sciences, National Science Foundation Graduate Research Fellowship Program

Awards: Next-generation Mass Spectrometry Technologies for Integrated Structural Proteomics- Renewal, G1734563460, G479929807

OpenAlex ID: W7159574299

FWCI: 1.545

Cites: 36

Cited by: 1

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