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Astrocyte–Neuron Crosstalk in Hypertension: Mechanisms and Therapeutic Significance

Year: 2026

Type: article

Abstract: Hypertension is a major global health challenge that poses a serious threat to cardiovascular function. Crosstalk between astrocytes and neurons plays a central role in blood pressure regulation within the central nervous system. As the prevalence of hypertension continues to increase, significant progress has been made in understanding the associated pathological mechanisms involving astrocytes and neurons. Accumulating evidence indicates that astrocytes engage in complex metabolic-immune networks to communicate with neurons, thereby contributing critically to the development and progression of hypertension. This review highlights recent advances in our understanding of the bidirectional regulatory mechanisms between astrocytes and neurons in the context of hypertension.

Source: Reviews in Cardiovascular Medicine

DOI: 10.31083/rcm47764

Authors: Mengyu Zhao, Huizhuo Jia, Na Li

Institution: Hebei University

Language: English

Topic: Blood Pressure and Hypertension Studies

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,200