Work

Organoid models: applications and research advances in gastric cancer

Year: 2026

Type: article

Abstract: Gastric cancer research necessitates representative experimental models due to its profound heterogeneity. This review summarizes the establishment of human gastric organoids derived from adult and pluripotent stem cells and categorizes five representative culture models, including recently developed bioengineered platforms. We synthesize recent applications of gastric organoid systems across major research contexts in gastric cancer and discuss their extension toward more complex co-culture configurations and therapy-associated tumor evolution models. Finally, this review outlines current technical, translational, and ethical challenges to provide an integrated perspective on the future development of gastric organoid-based research.

Source: Frontiers in Oncology

DOI: 10.3389/fonc.2026.1766571

Authors: Rui Ling, Yuning Wu, Zhiying Yan, Qingying Xian, Yunqian Chu, Wenyu Zhu

Institutions: Changzhou No.2 People's Hospital, Nanjing Medical University

Language: English

Topic: Cancer Cells and Metastasis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801