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Reduced skeletal muscle perfusion accompanies skeletal muscle atrophy after severe spinal cord injury

Year: 2026

Type: article

Study design: Observational Study

Abstract: First study to assess temporal blood flow/perfusion rates in paralyzed plantar flexor muscles throughout the acute to subacute period after SCI and to determine the relation with skeletal muscle capillarization. Results demonstrate that reduced skeletal muscle perfusion that develops in the paralyzed plantar flexor muscles throughout the acute to subacute post-SCI recovery period may be driven by reduced limb perfusion and damage to endothelial cells within skeletal muscle vasculature, independent of skeletal muscle capillarization.

Source: Journal of Applied Physiology

DOI: 10.1152/japplphysiol.00090.2026

Authors: Zachary S. Clayton, Branden L. Nguyen, Hui Jean Kok, Michael C. Reynolds, Christine F. Conover, Russell D. Wnek, Kinley H. Buckley, Jayachandra R. Kura, Dana M. Otzel, Yangyi E. Luo, Elisabeth R. Barton, Darren T. Beck, Danielle J. McCullough, Joshua F. Yarrow

Institutions: VA Eastern Colorado Health Care System, University of Colorado Anschutz, Indiana University School of Medicine, Veterans Health Administration, North Florida/South Georgia Veterans Health System, University of Florida, Edward Via College of Osteopathic Medicine

Language: English

Topic: Spinal Cord Injury Research

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Veterans Affairs, Office of Research and Development, National Institutes of Health, Rehabilitation Research and Development Service, Anschutz Medical Campus, University of Colorado, National Institute on Aging

Awards: G2882513419, G3803787375, G7850790128, G9000070284, G9000232911, G9000239970, Muscle and Bone Growth in Aging, Integrative Physiology of Aging Training Grant

OpenAlex ID: W7159658654

FWCI:

Cites: 52

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