Depletion of renal cortical collecting duct-secreted PCSK9 in early proteinuria prevents sustained nephrotic syndrome-related hypercholesterolemia
Year: 2026
Type: article
Abstract: The goal of this study was to investigate the biology of CCD-secreted PCSK9 and its role in MCD-associated hypercholesterolemia. PCSK9 expression was increased in the kidney, but reduced in the liver, suggesting that elevated circulating PCSK9 levels may originate from the kidney. Administration of anti-PCSK9 antibodies targeting circulating kidney-derived PCSK9 prevented the development of significant and sustained hypercholesterolemia in the PAN rat model of human MCD-associated nephrotic syndrome.
Institutions: Rush University Medical Center, University of Toronto
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7159668982