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CREST: A Concept for Electronics-Free, pH-Triggered Emergency Drug Delivery in Refractory Epilepsy

Year: 2026

Type: article

Abstract: This concept note proposes CREST — a subcutaneous implant designed to deliver emergency benzodiazepine medication during generalised tonic-clonic seizures without electronics or external triggers. The mechanism relies on seizure-induced lactic acidosis as a physiological trigger for pH-sensitive polymer erosion and controlled midazolam release. This document is an early-stage concept intended to establish date of priority and invite technical critique.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.19962123

Authors: Yasenovyi, Varfolomii, Pavlova, Yelyzaveta

Language: English

Topic: Epilepsy research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7159683962

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