Work

Soluble klotho levels and hip fracture risk in the elderly

Year: 2026

Type: article

Study design: Observational Study

Abstract: The association between circulating soluble klotho (s-klotho) levels and hip fracture risk is uncertain. We assessed this relationship in 4428 older adults followed for a median of 11.8 years, during which 602 hip fractures occurred. In the overall cohort, s-klotho levels were marginally but not significantly associated with hip fracture risk (hazard ratio (HR) per standard deviation increase, 0.92; 95% CI, 0.83-1.01; p = 0.075). In exploratory analyses, participants in the highest 5% of s-klotho levels (> 1615.2 pg/ml) exhibited a substantially lower risk of hip fracture (adjusted HR, 0.48; 95% CI, 0.27-0.85; p = 0.01), suggesting a threshold effect in which only very high s-klotho concentrations are associated with reduced risk. This finding may help explain inconsistencies in prior studies.

Source: Osteoporosis International

DOI: 10.1007/s00198-026-08053-y

Authors: Joshua I. Barzilay, Petra Bůžková, Howard A. Fink, Jane A. Cauley, John A. Robbins, Rachel Elam, Laura Carbone, Kenneth J. Mukamal

Institutions: Kaiser Permanente, Emory University, University of Washington, Minneapolis VA Health Care System, Minneapolis VA Medical Center, University of Pittsburgh, University of California, Davis, Augusta University, Beth Israel Deaconess Medical Center

Language: English

Topic: Bone health and osteoporosis research

Subfield: Orthopedics and Sports Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,090

Funders: National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Neurological Disorders and Stroke

Awards: G1023702118, G1097528416, G125972088, CORONARY HEART DISEASE AND STROKE, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, G1401438683, G1438302022, CORONARY HEART DISEASE AND STROKE, G1726490033, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, CORONARY HEART DISEASE &STROKE IN THE ELDERLY, G270907595, G2800149121, G3137375862, G3220743633, G322252321, G3256118428, G34347772, CHS research resources for the cardiovascular health of older adults, Non-esterified Fatty Acids and Cardiometabolic Disease in Older Adults, CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS, G4219624527, G423252844, G4622379297, G4942589162, G5145575165, G5148796768, G544148272, G5479317095, CHS Events Follow-up Study, CHS-Transition Phase, G7217924807, G764651519, G766700449, G766843672, Exceptional Survival: Trajectories to Functional Aging (CHS All Stars), G806768229, G8068269535, G8518686724, G8892155751, Kynurenine accumulation drives loss of muscle and bone function with aging, Infrastructure for mentored access to CHS data and specimens, G905887895

OpenAlex ID: W7159732131

FWCI: 6.734

Cites:

Cited by: 1

Related to: 10