Generation of four human induced pluripotent stem cell lines derived from patients with corticosteroid-associated central serous chorioretinopathy
Year: 2026
Type: article
Abstract: Peripheral blood from four male patients with corticosteroid-related central serous chorioretinopathy (CSC) was used to generate human induced pluripotent stem cells (hiPSCs). Non-integrating episomal vectors were employed to deliver the reprogramming factors. All hiPSCs displayed typical morphology, expressed markers of the undifferentiated state, demonstrated the ability to differentiate into the three-germ layers, and exhibited normal karyotypes. These hiPSC lines offer a valuable model to study CSC pathogenesis.
Source: Stem Cell Research
Authors: Sekar Galuh, Karine Raymond, Joost Brinks, Elon H.C. van Dijk, Christian Freund, Onno C. Meijer, Camiel J.F. Boon
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,360
Funders: Universiteit Leiden, ZonMw, Leids Universitair Medisch Centrum, Stichting MaculaFonds, Algemene Nederlandse Vereniging ter voorkoming van Blindheid, Landelijke Stichting voor Blinden en Slechtzienden, Stichting voor Ooglijders, Rotterdamse Stichting Blindenbelangen, Stichting Blinden-Penning, Stichting Leids Oogheelkundig Ondersteuningsfonds
OpenAlex ID: W7159794948