Work

Challenging the GalNAc dogma: intrinsic LNP chemistry enables LDLR-independent hepatic delivery

Year: 2026

Type: article

Abstract: Current dogma mandates GalNAc conjugation for LDLR-independent hepatocyte mRNA delivery. However, groundbreaking research from the Anderson and Dahlman labs, alongside Sanofi’s preclinical data, reveals that optimizing internal LNP architecture robustly bypasses the LDLR without complex surface ligands, streamlining future hepatic genetic medicines.

Source: Nucleic Acid Insights

DOI: 10.18609/nuc.2026.021

Author: Arnab Rudra

Institutions: Boston Children's Hospital, Koch Institute for Integrative Cancer Research At MIT, Massachusetts Institute of Technology

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7159795693

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