Year: 2026
Type: article
Abstract: Ceramides are central bioactive sphingolipids that regulate diverse cellular processes, including membrane organization, energy metabolism, and stress signaling. Emerging evidence has implicated that ceramide dysregulation is associated with the onset and progression of heart failure. This review introduces the understanding of ceramide metabolism, focusing on its biosynthesis, and functional roles in cardiomyocytes. In addition, the contribution of systemic ceramides derived from circulating lipoproteins and peripheral tissues to cardiovascular risk is also discussed. In parallel, it is highlighted that cardiomyocyte-intrinsic ceramide synthesis plays physiological and pathological roles in the heart. Particularly, excessive ceramide accumulation is detrimental for cardiac function, through multiple mechanisms, such as lipotoxic effects, mitochondrial impairment, inflammation, and cell death. The current review discusses the potential diagnostic and therapeutic strategies targeting ceramide metabolism, as well as the open questions about ceramide association with heart disease.
Source: Cells
Authors: Xinyi Chen, Oveena Fonseka, Yihua Han, Wei Liu
Institution: University of Manchester
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,258
Funder: British Heart Foundation
Awards: An investigation into the molecular basis and impacts of cardiac FGF21 resistance in response to metabolic stress, Investigate a novel regulation of cardiac lipid homeostasis in metabolic disorder, Does modulation of cardiac HMGB1 prevent myocardial inflammation in diabetes?, G38433669, Ability of FGFR1/KLB to prevent cardiac microvascular impairment and pathological remodelling in response to metabolic stress
OpenAlex ID: W7159805555
FWCI:
Cites:
Cited by:
Related to: