Work

Systemic inflammatory biomarkers linked to PKD1 mutation and renalmorphometrics in cats with polycystic kidney disease

Year: 2026

Type: article

Abstract: Background and Aim: mutation status, and renal morphometric changes in cats with polycystic kidney disease. Materials and Methods: mutation. Hematological inflammatory indices, including neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR), were calculated from routine blood profiles. Conventional renal biomarkers (creatinine, blood urea nitrogen, and symmetric dimethylarginine) and ultrasonographic renal morphometric parameters were also assessed. Correlations between inflammatory markers, renal measurements, biochemical indices, and genotype were analyzed using Pearson's correlation. Results: heterozygosity. Overall, systemic inflammatory indices demonstrated closer relationships with renal structure and function than traditional renal biomarkers during early disease stages. Conclusion: mutations. Simple hematological inflammatory ratios may serve as accessible adjunct tools alongside ultrasonography and genetic testing for the early detection and monitoring of feline PKD. Further longitudinal studies are warranted to validate their prognostic utility.

Source: Veterinary World

DOI: 10.14202/vetworld.2026.1495-1503

Authors: Kotchapol Jaturanratsamee, Palin Jiwaganont, Wannisa Meepoo, Ratikorn Bootcha, Soontaree Petchdee

Institution: Kasetsart University

Language: English

Topic: Veterinary Medicine and Surgery

Subfield: Small Animals

Field: Veterinary

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $600