Complement Anaphylatoxin C5a-Induced Mouse Lymphatic Functions Modulate Interactions Between Endothelial Cells and T Lymphocytes
Year: 2026
Type: article
Abstract: Th1 subtypes, indicating that C5a-activated endothelial-iNOS may contribute to Th1 polarization in the peripheral LNs during homing. Finally, we observed C5a-mediated endothelial surface glycoprotein CD146 interaction with Th1 cell intermediate filament protein vimentin that may facilitate transmigration of activated Th1 cells into systemic circulation and tissue interstitium. Given the critical role of the C5a/C5ar1 axis in promoting lymphatic dysfunction, our study highlights the therapeutic potential of targeting C5ar1 in chronic inflammatory conditions.
Source: Immune Network
Authors: Haydn E. Rich, Yi-Dong Li, Kathryn D. Hok, Stacey L. Mueller-Ortiz, Aleksey Y. Domozhirov, Anthony Shadid, Rajarajan A. Thandavarayan, Hari Krishna Yalamanchili, Marie-Francoise Doursout, Tingting Weng-Mills, Faraz Bishehsari, Nirmal K. Banda, Kristin L. Eckel-Mahan, Marcos I. Restrepo, Pooja Shivshankar
Institutions: Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, Houston Methodist, Baylor College of Medicine, University of Colorado Anschutz, The University of Texas at San Antonio Health Science Center, Audie L. Murphy Memorial VA Hospital, South Texas Veterans Health Care System
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W7159856641