Effects of Deep versus Moderate Neuromuscular Blockade on Postoperative Acute and Chronic Pain in Laparoscopic Gynecological Surgery
Year: 2026
Type: report
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Ying Zhao, Jingjing Zhang, Wei Qian, Hailing Mu, Qiushuang Tang, Peng Zhang Department of Anesthesiology, The Second People’s Hospital, Wuhu, Anhui, People’s Republic of ChinaCorrespondence: Peng Zhang, Department of Anesthesiology, The Second People’s Hospital, Wuhu, Anhui, People’s Republic of China, Tel +86 180 5531 6106, Email [email protected]: To evaluate the effects of deep neuromuscular blockade (D-NMB) versus moderate NMB (M-NMB) on postoperative pain and chronic postsurgical pain (CPSP) in patients undergoing laparoscopic gynecological surgery.Patients and Methods: Seventy-two patients scheduled for laparoscopic uterine or adnexal surgery were randomly assigned to Group D (D-NMB, post-tetanic count 1– 2) or Group M (M-NMB, train-of-four count 1– 2). Postoperative pain was assessed using the visual analogue scale (VAS) at multiple time points. Surgeon satisfaction score (SRS), opioid consumption, Quality of Recovery-15 (QoR-15) score, and CPSP incidence at 3 and 6 months were compared.Results: The VAS score at 0.5 hours postoperatively was significantly lower in Group D than in Group M (4.18± 1.40 vs. 5.42± 1.61, P=0.001). Postoperative opioid consumption and the proportion requiring additional analgesia were significantly reduced in Group D (P=0.011 and P=0.019, respectively).SRS and QoR-15 scores were significantly higher in Group D (P< 0.001 and P=0.022, respectively). No significant differences were observed in CPSP incidence or adverse reactions between the two groups.Conclusion: D-NMB improves early postoperative pain control, reduces opioid requirements, and enhances surgeon satisfaction and early recovery quality without increasing adverse events, but does not reduce CPSP incidence.Keywords: neuromuscular blockade, postoperative pain, deep neuromuscular blockade, chronic postsurgical pain
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7159892252
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