Cumulative Triglyceride-Glucose Index and Risk of Metabolic Dysfunction–Associated Fatty Liver Disease: Findings from the Kailuan Cohort
Year: 2026
Type: article
Study design: Observational Study
Abstract: Chao Zhang,1 Zixin Zhang,2,3 Qi Qi,2,3 Lei Li,3 Jie Deng,3 Jiao Zheng,3 Yue Jiang,1 Quanle Han,3 Shouling Wu,4 Kangbo Li5 1Catheterization Unit, Tangshan Gongren Hospital, Tangshan, People’s Republic of China; 2Hebei Medical University, Shijiazhuang, People’s Republic of China; 3Department of Cardiology, Tangshan Gongren Hospital, Tangshan, People’s Republic of China; 4Department of Cardiology, Kailuan General Hospital, Tangshan, People’s Republic of China; 5School of Clinical Medicine, North China University of Science and Technology, Tangshan, People’s Republic of ChinaCorrespondence: Quanle Han, Department of Cardiology, Tangshan Gongren Hospital, No. 27, Wenhua Road, Lubei District, Tangshan, 063000, People’s Republic of China, Email [email protected]: This study aimed to investigate the relationship between the cumulative triglyceride-glucose (cum-TyG) index and the risk of new-onset metabolic dysfunction-associated fatty liver disease (MAFLD).Patients and Methods: The present study involved 89,831 participants selected from the Kailuan cohort. The cum-TyG index was evaluated by determining the weighted average of TyG index values recorded at each visit. Participants were divided into four groups based on the quartiles of cum-TyG index or the duration of high TyG index exposure. To investigate the association between levels of the cum-TyG index and the risk of new-onset MAFLD, Cox proportional hazards regression analysis was performed.Results: A total of 16,387 cases of new-onset MAFLD were recorded over a median follow-up duration of 10 years. The Cox proportional hazards regression analysis indicated that the hazard ratios (HRs) and 95% confidence intervals (CIs) significantly increased in quartile 2 (HR: 1.306, 95% CI: 1.246– 1.367), quartile 3 (HR: 1.423, 95% CI: 1.357– 1.492), and quartile 4 (HR: 1.648, 95% CI: 1.571– 1.730), when compared to quartile 1. A similar pattern was noted for 2-year high TyG index exposure (HR: 1.267, 95% CI: 1.200– 1.338), 4-year high TyG index exposure (HR: 1.642, 95% CI: 1.557– 1.731), and 6-year high TyG index exposure (HR: 2.122, 95% CI: 2.010– 2.239), when compared to 0-year high TyG index exposure.Conclusion: The cum-TyG index may provide important information for risk assessment of MAFLD.Keywords: insulin resistance, the cumulative triglyceride-glucose index, metabolic-dysfunction associated fatty liver disease
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7159904312
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