Work

Naringenin-Mn self-fueling dual-dynamic hydrogel with cascade catalysis and immunomodulation properties for repairing MRSA-infected diabetic wounds

Year: 2026

Type: article

Abstract: Chronic infectious wounds in diabetic patients remain a significant clinical challenge due to persistent inflammation, oxidative stress, and bacterial resistance issues. This problem is particularly acute in the area of postoperative surgical incisions, where impaired healing can lead to serious complications. This study aimed to develop a self-healing cascade-catalyzed hydrogel, CS-PBA/ODex@NRGe-Mn (CPONM), featuring borate and Schiff base bonds. This hydrogel exhibits a dual dynamic network structure and incorporates naringenin-Mn nanoparticles (NM NPs) with SOD/POD-like activity. The hydrogel was synthesized by mixing CS-PBA solution with ODex solution containing NM NPs. CPONM exhibits high porosity, swelling capacity, adhesion strength (13.43 kPa), and pH-responsive release properties. In vitro studies demonstrated that CPONM effectively inhibited the growth of Escherichia coli (E.coli, 93.15%) and methicillin-resistant Staphylococcus aureus (MRSA, 94.74%), disrupted bacterial biofilms by up to 92%, and reduced iNOS and IL-6 expression in macrophages. In a diabetic mouse wound model infected with MRSA, CPONM accelerated wound healing (reaching 97.47% by day 18), reduced bacterial infection risk, inhibited NF-κB, and activated Nrf2. Histopathological staining revealed the hydrogel's ability to promote wound epithelialization, collagen deposition, and vascular growth (VEGF, α-SMA). Therefore, CPONM represents a promising approach for treating infected postoperative wounds in diabetic patients.

Source: Materials Today Bio

DOI: 10.1016/j.mtbio.2026.103787