Year: 2026
Type: article
Abstract: Alkene 1,1-difunctionalization holds significant importance in organic synthesis due to its ability to effectively enhance the complexity and functionality of molecular frameworks. Herein, we report an electrochemical strategy for 1,1-difunctionalization of halogenated aromatics with unactivated alkenes using synergistic Fe/Ni catalysis. This system integrates redox activity of nickel with Lewis acid functionality of iron: the nickel catalyst governs aryl halide oxidative addition and alkene migration, while iron species activates catalytic sites, stabilizes radical acceptors, and precisely regulates electrochemical reduction sequences/selectivities. The reaction system is applicable to a wide range of substrates, including electron-rich and electron-deficient aryl halides, polycyclic compounds, and bioactive natural products (100 examples). Gram-scale synthesis maintains 63% yield, supporting industrial viability. Mechanistic studies elucidate the unique cooperativity of this iron-nickel bimetallic system, providing a theoretical framework for the design of diverse difunctionalization reactions.
Source: Nature Communications
Authors: Pengwei Hu, Chao Yang, Lin Guo, Wujiong Xia
Institutions: Harbin Institute of Technology, Henan Normal University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $6,990
Award: G8229000284
OpenAlex ID: W7159943980
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