Work

Regressive Neuroblastoma: Widely Accepted, Underreported Histology

Year: 2026

Type: article

Abstract: Neuroblastoma accounts for approximately 8% of all pediatric cancers and up to 15% of pediatric cancer-related deaths in malignant cases; neuroblastoma is the most common malignancy in infancy. Notably, up to 50% of tumors may undergo spontaneous regression without treatment. However, detailed histological descriptions of regressed neuroblastoma remain limited in the literature. We report the histological features of a particularly illustrative case, characterized by edema, mild collagen deposition, evidence of prior hemorrhage, and calcifications. Cellularity was minimal, consisting of rare, scattered mature-appearing ganglion cells, without neuropil or neuroblastic clusters. Accurate recognition of these morphological features in surgical specimens is essential for optimal treatment planning.

Source: Clinical Case Reports

DOI: 10.1002/ccr3.72640

Authors: Tom Membrez, Jim C. H. Wilde, Oliver Sanchez, Danai Papangelopoulou, Fabienne Gumy‐Pause, Anne‐Laure Rougemont

Institutions: University of Geneva, University Hospital of Geneva

Language: English

Topic: Neuroblastoma Research and Treatments

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,820