Work

Physical activity and biological ageing: the need for stronger causal evidence

Year: 2026

Type: article

Abstract: DNA methylation (DNAm) is a widely studied epigenetic mechanism that regulates gene expression without altering the underlying DNA sequence itself. DNAm patterns are influenced by both genetic and environmental factors; DNAm-based measures to assess biological ageing, which are often referred to as epigenetic clocks, have been developed in the last two decades. The first-generation clocks, such as Horvath’s clock,1 are trained to predict chronological age using genome-wide DNAm levels, whereas second-generation clocks, such as DNAm GrimAge,2 use information on mortality and clinical biomarkers to better capture age-related health.

Source: The Lancet Healthy Longevity

DOI: 10.1016/j.lanhl.2026.100845

Authors: Anna Kankaanpää, Elina Sillanpää

Institution: University of Jyväskylä

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $6,680