A serendipitous product of the reaction of famotidine with copper(II)
Year: 2026
Type: article
Abstract: Reaction of CuCl 2 and the anti-ulcer drug famotidine in aqueous solution results in hydrolytic cleavage of the organic molecules with loss of sulfonamide fragments and subsequent crystallization of a new Cu complex, dichlorido{3-[(2-guanidinothiazol-4-yl)methylsulfanyl]propanoic acid}copper(II) monohydrate, [CuCl 2 (C 8 H 12 N 4 O 2 S 2 )]·H 2 O ( 1 ). The Cu II ions adopt a square-pyramidal environment with the basal plane comprising one chloride ion and the organic ligand acting as the N,N,S-donor bis-chelate tridentate group. The second chloride ion resides in the apical position and it completes the electrically neutral complex. The supramolecular landscape is dominated by conventional hydrogen bonding involving strong hydrogen-bond donors and acceptors [O(N)H...O and O(N)H...Cl], which assemble the complex units and solvent water molecules into bilayers parallel to the bc plane. The primary significance of the contacts with H atoms was assessed with the results of Hirshfeld analysis, which suggest a 51.3% contribution of such contacts to the surface of individual complex molecules. The relatively short chalcogenide bonds [S...O = 3.006 (2) Å] and NH 2 (guanidine)-π interactions are also relevant to the packing. The chemical identity of 1 and the bulk sample is confirmed by elemental analysis, IR spectroscopic and thermogravimetric data.
Language: English
Subfield: Inorganic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $500
OpenAlex ID: W7159965147