Work

Personalized Dosage System as a Tool for Detecting Adverse Drug Reactions: Pharmaceutical Intervention in a Polymedicated Patient

Year: 2026

Type: article

Abstract: Adverse Drug Reactions (ADRs) represent a major public health concern due to their impact on patient safety. In Spain, the Spanish Agency of Medicines and Medical Devices, through the FEDRA database, coordinates the reporting of suspected ADRs under real-world conditions of use, contributing to the continuous updating of safety information. In this context, community pharmacist, through Professional Pharmaceutical Care Services, plays a key role in the early detection of ADRs and Drug-Related Problems (DRPs). This article describes the case of a 70-year-old polymedicated woman included in a Personalized Dosage System (PDS). Following the substitution of diazepam with clonazepam and an increase in the dose of semaglutide, the patient developed urinary incontinence, nausea and abdominal pain. Coordinated intervention between the community pharmacy and primary care enabled adjustment of the clonazepam dose, optimization of semaglutide administration and discontinuation of unnecessary naproxen use. These measures resulted in improved treatment tolerance and safety, as well as optimization of pharmacotherapy.

Source: Scientia Pharmaceutica

DOI: 10.3390/scipharm94020035

Authors: Adama Peña-Vera, Sandra Dévora-Gutiérrez, Chaxiraxi Morales Marrero, Isabel V. Figueiredo, Susana Abdala Kuri

Institutions: Universidad de La Laguna, Centro de Inovação em Biomedicina e Biotecnologia, University of Coimbra

Language: English

Topic: Pharmaceutical Practices and Patient Outcomes

Subfield: Geriatrics and Gerontology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,207