Year: 2026
Type: article
Abstract: Usual interstitial pneumonia (UIP) is a common pattern in fibrotic lung diseases characterized by distinctive radiological and histopathological features. UIP is associated with various underlying causes including idiopathic UIP, i.e. idiopathic pulmonary fibrosis (IPF), and secondary UIP, e.g. connective tissue disease-associated interstitial lung diseases (CTD-ILDs) and fibrotic hypersensitivity pneumonia (fHP). Previous work suggests radiological UIP patterns have strong correlations with overall poor prognosis. This review synthesizes current knowledge on the diverse entities of fibrotic lung diseases presenting with the UIP pattern. This review also highlights previous studies in biomarker searching of IPF and secondary UIP. A number of biomarkers associated with disease diagnosis are summarized, providing new insights for clinicians in disease differentiation. Finally, this review emphasizes the future directions of differential diagnosis through radiology- and blood- biomarkers with the integration of artificial intelligence (AI).
DOI: 10.7150/ijms.129394
Authors: Yuhang Cheng, Qing Chang, Feng Li
Institutions: Shanghai Jiao Tong University, Shanghai Chest Hospital
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,337
Awards: G4804211158, G5888408915
OpenAlex ID: W7160040046
FWCI:
Cites:
Cited by:
Related to: