Work

A systematic review on the modulation of heat shock protein 70 in broilers at different stages of growth under thermal stress

Year: 2026

Type: review

Abstract: This systematic review synthesises evidence from published articles investigating nutritional strategies tomodulate heat shock protein70 (HSP70). Atotal of1616 records were identified from four databases and snowballing. After screening and eligibility assessment, 25studies comprising 29reports published between 2004 and 2025 were included. The analysis shows that targeted interventions particularly antioxidants (vitaminsC, E, and selenium), amino acids and their derivatives (methionine, betaine), and phytogenic compounds effectively downregulate HSP70 expression inadose ortissue-dependent manner. This modulation isassociated with improved growth performance, enhanced redox balance, and normalised stress hormone profiles. Key findings indicate that synergistic combinations outperform single additives insuppressing HSP70 and improving carcass yield under chronic heat stress (32–38C); the early-life nutrient delivery modulates HSP70 expression and influences post-hatch thermotolerance; and organic mineral or methionine hydroxy analogue are more effective than inorganic forms. However, efficacy varies by life stage, with most studies focused on Ross and Cobb genotypes, and is influenced by gut microbiota interactions. Major research gaps remain, including defining stage-specific optimal HSP70 thresholds, clarifying links between HSP70 modulation, immunity or gut health, understanding long-term effects of early-life nutritional programming, and determining the influence of administration routes on nutrient efficacy.

Source: Czech Journal of Animal Science

DOI: 10.17221/1/2026-cjas

Authors: Hudu Ramalan Abdullahi, Abubakar Abubakar Ahmed, Suriya Kumari Ramiah, Hasliza Abu Hassim, Yong Meng Goh

Institutions: Universiti Putra Malaysia, Federal University Lafia, IMU University

Language: English

Topic: Animal Nutrition and Physiology

Subfield: Animal Science and Zoology

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDGs: Zero hunger, Good health and well-being

Open Access status: gold

Estimated APC paid: $609