Work

Duodenal mucinous adenocarcinoma in a dog: Correlation between cytology, histopathology and proliferation index

Year: 2026

Type: article

Abstract: An 8‐year‐old female Schnauzer presented with chronic postprandial vomiting. Abdominal ultrasonography revealed a thickened duodenal segment with loss of wall layering and decreased mesenteric reactivity. Exploratory laparotomy and segmental duodenectomy were performed on the patient. Intraoperative cytology revealed cohesive clusters of atypical epithelial cells with a mucinous background. Histopathology confirmed infiltrative mucinous adenocarcinoma, characterised by disorganised neoplastic glands, extracellular mucin lakes and occasional signet‐ring cells. Immunohistochemistry revealed a high Ki67 proliferation index (∼80%) and focal cyclooxygenase‐2 (COX‐2) expression. No postoperative complications were noted; however, no adjuvant treatment was performed, and long‐term follow‐up was unavailable. This case highlights the diagnostic value of intraoperative cytology and histological features of mucinous adenocarcinoma and potential role of Ki67 and COX‐2 as prognostic markers.

Source: Veterinary Record Case Reports

DOI: 10.1002/vrc2.70466

Authors: Rafaela Lima Coppo, Luisa Frasson Vieira, Haide Valeska Sheid, Igor Ribeiro Santos, Clairton Marcolongo‐Pereira

Institutions: Centro Universitário do Espírito Santo, Universidade Federal de Pelotas, University of Guelph

Language: English

Topic: Veterinary Oncology Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,480