Work

Pan-Cancer Analysis of Molecular Characteristics and Oncogenic Role of PRMT5 in Human Cancers

Year: 2026

Type: article

Abstract: Accumulating evidence supports the involvement of PRMT5 in cancer development; however, its cross-cancer molecular features remain incompletely characterized. Here, we performed an integrated pan-cancer analysis of PRMT5 and complemented the in silico results with PRMT5 knockdown experiments in three representative cancer cell lines. PRMT5 was upregulated in most cancers and showed cancer-type specific prognostic associations. Immune infiltration analysis revealed that PRMT5 expression was associated with an immunosuppressive microenvironment, characterized by reduced CD8+ T-cell levels in CESC and SKCM and elevated fibroblast recruitment across a broad spectrum of tumors, such as LIHC and PAAD. Enrichment analysis suggested that PRMT5-associated networks were linked to DNA/RNA metabolism and stress-response pathways. In vitro, PRMT5 silencing reduced proliferation, migration and stemness-associated features of carcinoma cells. Together, our analysis provides a cross-cancer resource for understanding PRMT5 and supports further evaluation of PRMT5 as a potential biomarker and therapeutic target in selected tumor contexts.

Source: Journal of Oncology Translational Research

DOI: 10.5281/zenodo.20019638

Authors: Kunpeng, Jia, Lexi, Huang, Yuanhao, Xu, Lingjiao, Xiang

Institutions: Zhejiang University, Qilu University of Technology, Shandong Academy of Sciences, Sichuan University

Language: English

Topic: Cancer-related gene regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7160147078

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