Work

Prussian Blue Nanoparticles Confined in Chitosan for In Vivo Cesium Ion Removal

Year: 2026

Type: article

Abstract: The development of efficient and biocompatible sorbent nanomaterials for cesium removal is critical for environmental and biomedical decontamination. Here, hybrid composites based on ultra-small Prussian blue or Zn Prussian blue-type nanoparticles confined within porous chitosan beads are proposed for Cs+ extraction. Nanoparticle confinement ensures homogeneous dispersion and improved accessibility of ion-exchange sites, while preserving the porous polymeric network, as confirmed by physicochemical characterization. Cs+ adsorption was investigated under neutral and acidic conditions (pH 7.2 and 1.2), at concentrations of 0–9 mmol/L and contact times of 0–50 h, showing efficient uptake and favorable kinetics, with confirmed stability in simulated gastric fluid. In vivo performance was assessed in a mouse model of cesium contamination (70 mg Cs+/kg). Treatment with nanocomposites (225 mg/kg) was compared to bulk Prussian blue (75 mg/kg), revealing enhanced detoxification efficiency. Histological analysis of liver, spleen, and kidney tissues showed no detectable structural damage, consistent with unchanged systemic biomarkers. Overall, the proposed chitosan-confined Prussian blue-type nanocomposites combine high Cs+ removal efficiency, kinetic accessibility, and in vivo safety, highlighting their potential for decorporation applications.

Source: Nanomaterials

DOI: 10.3390/nano16090544