Severe hypocalcaemia with elevated PTH and normal vitamin D: a diagnostic pitfall due to chronic negative calcium balance in a vegan patient
Year: 2026
Type: article
Study design: Case Report
Abstract: Introduction: Secondary hyperparathyroidism is usually associated with chronic kidney disease or vitamin D deficiency. Case description: A 62-year-old man with severe osteoporosis presented with persistent hypocalcaemia and markedly elevated parathyroid hormone levels. Renal function, phosphate and vitamin D levels were normal. Extensive investigations excluded common causes. Twenty-four-hour urinary calcium excretion was profoundly reduced, indicating a chronic negative calcium balance. Dietary assessment revealed a strict vegan diet with low calcium intake and reduced bioavailability. Treatment with calcium citrate and calcitriol normalised serum calcium and reduced PTH levels. Conclusion: A chronic negative calcium balance is an under-recognised cause of secondary hyperparathyroidism. Measurement of urinary calcium is a key diagnostic tool in these patients. LEARNING POINTS: Secondary hyperparathyroidism may occur despite normal vitamin D and phosphate levels.Very low urinary calcium excretion is a key diagnostic clue in hypocalcaemia with elevated parathyroid hormone.A chronic negative calcium balance should be considered in patients with restrictive diets such as veganism.
DOI: 10.12890/2026_006604
Author: Manuel Serrano Quero
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $323
OpenAlex ID: W7160161675