Work

Immunologic Combinations in Multiple Myeloma: Synergistic Stimulation with T cells and NK cells

Year: 2026

Type: article

Abstract: Bone marrow plasma cells proliferate malignantly in multiple myeloma (MM), a hematological cancer. MM is now the second most common hematologic illness, followed by non-Hodgkin's lymphoma. The tumor microenvironment (TME) is a crucial factor in MM development. T cells, natural killer (NK) cells, and natural killer T (NKT) cells are the key anti-MM immune cells in the bone marrow microenvironment (BMME). By direct contact or cytokine production, these cells prevent MM cells from proliferation and survival. However, a major factor contributing to the insufficiency of anti-tumor immune responses is the inhibition of T cells and NK cells functions. We aimed to summarize the mechanisms of T cells and NK cells suppression in MM and discuss emerging immunotherapies that target both cell types.

Source: International Journal of Biological Sciences

DOI: 10.7150/ijbs.127871