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Granulomatous Inflammation Mimicking Metastatic Malignancy on 18F-FDG PET/CT

Year: 2026

Type: article

Abstract: 18F-FDG PET/CT is an essential imaging modality in oncologic diagnostics, yet its limited specificity can pose challenges in differentiating malignancies from benign FDG-avid conditions such as granulomatous diseases. We present the case of a 67-year-old woman with systemic symptoms and widespread FDG-avid lesions in the liver, spleen, bones, and lymph nodes, initially suggestive of malignancy. However, extensive histopathologic evaluations from multiple sites revealed noncaseating granulomatous inflammation with no evidence of malignancy or infection. This case highlights the diagnostic complexity posed by granulomatous diseases on FDG PET/CT and underscores the importance of multisite tissue sampling in ambiguous cases.

Source: Clinical nuclear medicine open.

DOI: 10.1097/nm9.0000000000000060

Authors: Mohadeseh Bayat, Parva Javan-Shayani, Mohammadali Ghodsirad

Institutions: Taleghani General Hospital, Shahid Beheshti University, Shahid Beheshti University of Medical Sciences

Language: English

Topic: Lymphadenopathy Diagnosis and Analysis

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7160193864

FWCI:

Cites: 5

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