Prognosis of Pregnancies Complicated by OHSS Following Ovulation Induction: A Retrospective Analysis
Year: 2026
Type: article
Study design: Observational Study
Abstract: Objective: This research investigates pregnancy outcomes in women who developed ovarian hyperstimulation syndrome (OHSS) after ovulation induction, with a focus on both maternal and newborn health.The study further explored how OHSS relates to unfavorable pregnancy outcomes, including the need for neonatal intensive care, the occurrence of multiple gestations, and complications affecting the mother.Methods: Between January 2019 and August 2022, a retrospective evaluation was carried out in one tertiary-level hospital.The study population consisted of pregnant women who developed OHSS following ovulation induction.Data on demographic features, clinical findings, laboratory measurements, and pregnancy-related results were collected.Comparative statistical analyses were used to examine how OHSS influenced both maternal and newborn complications.Results: The mean age of the study population was 31.1±5.1 years, and the mean body mass index was 30.5±1.4 kg/m 2 .In vitro fertilization was the most commonly applied assisted reproductive technique, used in 60.0% of cases.Clinical symptoms were prevalent, with abdominal pain reported in 86.7% of patients, and nausea/vomiting in 73.3% of patients.The live birth rate was 66.7%, while pregnancy loss occurred in 33.3% of cases.Multiple pregnancy was present in 40.0% of cases, and neonatal intensive care unit (NICU) admission was required in 50.0% of newborns, with a statistically significant association between NICU admission and multiple pregnancy (p=0.010).Maternal adverse outcomes were observed in 63.6% of cases, and these were significantly correlated with higher albumin levels (p=0.002) and lower gestational age (p=0.030).However, OHSS was not identified as an independent risk factor for cesarean delivery, preterm birth, or pregnancy loss.Conclusion: Our findings align with existing literature suggesting that OHSS is associated with neonatal morbidity and maternal complications but may not be an independent risk factor for adverse pregnancy outcomes.Differences in patient populations and inclusion criteria may explain variations across studies.To clarify the long-term influence of OHSS on pregnancy outcomes, additional research with broader sample sizes and prospective designs is required.
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7160204609