Associations of general adiposity, abdominal adiposity and their changes with fracture risk in Chinese individuals with type 2 diabetes: a population-based cohort study in Hong Kong
Year: 2026
Type: other
Abstract: Objective: To investigate the associations of baseline general and abdominal adiposity, as well as their longitudinal changes, with risks of any-site fracture, major osteoporotic fracture (MOF) and site-specific fractures in individuals with type 2 diabetes. Research Design and Methods: Individuals with type 2 diabetes who underwent structured assessments in the Hong Kong Hospital Authority between August 2001 and February 2022 were followed for incident fractures until June 2024. Multivariable Cox regression and restricted cubic spline analyses were used to evaluate the associations of baseline body mass index (BMI), waist circumference, and their 2-year percentage changes with fracture risk. Results: Among 436,929 individuals (mean [SD] age, 61.9 [11.8] years; median [IQR] diabetes duration, 1 [0-6] years; 53.1% men) followed for a median of 8.3 years, underweight was associated with 30%-77% higher risks of any-site, MOF, hip and pelvis fractures, whereas class II obesity was associated with 21%-36% higher risks of humerus, upper leg and ankle fractures. Waist circumference residuals from BMI were positively associated with fracture risk. Among 247,540 individuals with 2-year adiposity measurements, weight change showed U-shaped associations with any-site, MOF, hip and humerus fractures, with the lowest risks at -1.5% to 2.3% weight change. Increases in waist circumference were positively associated with risks of any-site, MOF, hip, rib, humerus and elbow fractures. Conclusions: In individuals with type 2 diabetes, general adiposity showed site-specific associations, with its longitudinal changes demonstrating U-shaped associations with fracture risk, whereas abdominal adiposity and its increases were independently associated with higher fracture risk.
Language: English
Subfield: Orthopedics and Sports Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7160213194