Work

Synergistic combination of taxifolin and baicalein protects against alloxan-induced diabetic cardiomyopathy by mitigating oxidative stress through the Nrf2/HO-1 signaling pathway

Year: 2026

Type: article

Abstract: OBJECTIVE: To investigate the cardioprotective effects of taxifolin (TXN) and baicalein (BCN) in an alloxan-induced diabetic rat model. METHODS: cytotoxicity assays were conducted on H9c2 cardiomyocytes. RESULTS: studies demonstrated no cytotoxicity for TXN and BCN. CONCLUSION: TXN and BCN exhibit cardioprotective effects in diabetic rats by improving glucose metabolism, modulating lipid profiles, and enhancing antioxidant defense through the Nrf2 signaling pathway. These findings suggest that TXN and BCN hold promise as potential therapeutic agents for the prevention and treatment of diabetic cardiomyopathy.

Source: American Journal of Translational Research

DOI: 10.62347/ptmm9015

Author: Qingsong Liang

Institution: The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)

Language: English

Topic: Genomics, phytochemicals, and oxidative stress

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7160387278

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