Abstract Number: Esoc2026a500 Associations of Computed Tomography Angiography-based Plaque-rads Subtypes With Symptomatic Carotid Atherosclerosis
Year: 2026
Type: conference-abstract
Abstract: Background and aims Carotid Plaque-RADS (Plaque Reporting and Data System) scoring offers a reproducible framework to characterize internal carotid artery (ICA) plaque morphology across imaging modalities. This study investigated associations between Computed Tomography Angiography (CTA)-based Plaque-RADS subgroups and recurrent vascular events in patients with non-cardioembolic stroke/TIA. Methods Baseline CTAs from 517 patients in the CONVINCE (Colchicine for prevention of vascular inflammation in Non-CardioEmbolic stroke) trial were analyzed. Plaque-RADS scoring assigned ICA’s to the following subgroups: (1) no plaque, (2) plaque thickness < 3 mm, (3a) thickness ≥ 3 mm, (3c) ulceration, (4a) intraplaque hemorrhage, and (4c) intraluminal thrombus. In ICA’s ipsilateral to the index ischaemic lesion, Cox proportional hazards models were used to assess associations with subsequent ipsilateral ischaemic stroke, any stroke/TIA, and major adverse cardiovascular events (MACE), using both ordinal (per-level increase) and binary (RADS < 3 vs ≥3) classifications. Results Available data from 510 patients (median age 67.0 years, 27.8% female, 966 ICA’s were analyzed. Among 321 ICA’s (33.2%) ipsilateral to the index event, recurrent ipsilateral stroke occurred in 12 (3.7%), any stroke/TIA in 32 (10.0%), and MACE in 37 patients (11.5%) during a median follow-up of 35.7 months. Per-level increases in Plaque-RADS scores were associated with an increased risk of ipsilateral stroke (HR 1.48, 95%CI 1.07-2.05) and any stroke/TIA (HR 1.32, 95%CI 1.08–1.61), but not MACE (Table 1). Binary analyses showed strong associations with all endpoints (Table 2). Conclusions In ICA’s ipsilateral to the index ischaemic lesion, higher Plaque-RADS scores were associated with an increased risk of subsequent vascular events. Conflict of interest Darragh Nerney should also be considered an author. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. Figure 1 - belongs to Methods Table 1 - belongs to Results Table 2 - belongs to Results
Source: European Stroke Journal
Authors: Louise Maes, Jo P P Peluso, Jelle Demeestere, Anke Wouters, Philippe Desfontaines, Adinda De Pauw, Rónán Collins, Dominick J H McCabe, Simon Cronin, David Williams, Sylvie De Raedt, Francisco Purroy, Geert Vanhooren, George Pope, Peter Vanacker, Tim Cassidy, Cathal Walsh, Daniel Bos, Peter Kelly, Robin Lemmens
Institutions: Universitair Ziekenhuis Leuven, KU Leuven, Centre Hospitalier Chrétien, Damiaan Dicht bij het leven, Trinity College Dublin, Tallaght University Hospital, Health Research Board, University College Cork, Cork University Hospital, Royal College of Surgeons in Ireland, Beaumont Hospital, Vrije Universiteit Brussel, Universitair Ziekenhuis Brussel, Universitat de Lleida, Hospital Universitari Arnau de Vilanova, Instituto de Investigación Biomédica de Lleida, AZ Sint-Jan, University Hospital Waterford, University of Antwerp, AZ Groeninge, Antwerp University Hospital, St. Vincent's University Hospital, Erasmus MC, University College Dublin, Mater Misericordiae University Hospital
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,400
OpenAlex ID: W7160424798
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