Correction: Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach
Year: 2026
Type: erratum
Abstract: The authors of the original article “Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach” (DOI: 10.1042/BCJ20240608) would like to correct the Figure Legend of Figure 5. The authors state that the data have been incorrectly presented as as mM rather than μM, resulting in a 1000-fold under-representation of efficacy. They have confirmed that the logged data are correct and aligns with the graphs.The requested correction has been assessed and approved by the Editorial Board. The authors declare that these corrections do not change the results or conclusions of their paper.The corrected Figure Legend reads as follows:Chemical structures of (A) DDD1060606 and (B) DDD1870799. DDD1060606 and DDD1870799 showed >80% inhibition of HsRNMT-RAM activity with determined pIC50s (negative logarithm of half-maximal inhibitory concentration [molar]) of 5.5 ± 0.2 (IC50 3 μM; Figure 6D and 5.0 ± 0.2 (IC50 10 μM; Figure 6G), respectively.
Source: Biochemical Journal
Institutions: University of Dundee, University of Glasgow
Language: English
Topic: RNA modifications and cancer
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W7160430412
Cites:
Cited by:
Related to: