Abstract Number: Esoc2026a585 Time in Glycemic Range Versus Hyperglycemia Exposure: Identifying the Best Prognostic Metric in Ischemic Stroke. the Glias-iii Study
Year: 2026
Type: conference-abstract
Abstract: Background and aims Post-stroke hyperglycemia has a well-known negative prognostic value in acute ischemic stroke (AIS). Continuous glucose monitors (CGM) provide an opportunity to analyze other metrics of glucose control such as time in range (TIR) and time above range (TAR). We aim to explore which of them provides a better prognostic prediction. Methods The GLycemia In Acute Stroke (GLIAS) III is a multicenter cohort prospective study. Blinded CGMs were implanted within the first 24 h. We defined TIR as the proportion of time within 70-150 mg/dL and TAR as the proportion of time with values above 150 mg/dL. Adjusted multivariate models for death or dependence at 3 months were built. Results A total of 153 patients were included (61 female;39.9%). CGMs were implanted a median of 18 hours (IQR 10.98-21.98) after stroke onset. The median duration of monitoring was 84.67 hours. 45 patients (29.4%) were dead or dependent at 3 months. Their median TIR was slightly lower than in independent patients (89% vs 93%; P=0.100) while mean TAR was significantly higher (8% vs. 2%). A non-significant gradient between TIR quartile and death or dependence was observed (Q1 47.1%, Q2 33.3%, Q3 26.7%, Q4 23.5%). Adjusted multivariate analysis showed that TAR was associated with a higher likelihood of death or dependence (OR 1.018; 95%CI 1.004-1.032) whilst TIR was not (OR 0.98; 95%CI 0.969-1.006). Conclusions In this prospective, multicenter cohort study, time above 150 mg/dL was a better metric to predict death or dependence at 3 months in patients with AIS. Conflict of interest The study was investigator-initiated, promoted and coordinated by the Research Foundation of the La Paz University Hospital (Fundación de Investigación del Hospital Universitario La Paz) and was co-funded by grants (PI18/00991, PI21/00962) from the Carlos III Health Institute (ISCIII) Health Care Research Fund and the European Regional Development Fund (ERDF). Conflict of interest statement for all the authors: nothing to disclose
Source: European Stroke Journal
Authors: Silvia Pastor Yvorra, Noemí González-Pérez de Villar, Maria del Mar Freijo, Mar Castellanos, Noemi Diez, María Santamaria Cadavid, Laura Amaya-Pascasio, Arturo Fraga-Bau, Raquel Delgado-Mederos, Ana Isabel Calleja Sanz, Juan Carlos Portilla, M Angeles Ortega-Casarrubios, Blanca Fuentes, Elena de Celis Ruiz
Institutions: Hospital Universitario La Paz, Hospital La Paz Institute for Health Research, Universidad Autónoma de Madrid, Hospital de Cruces, Universidade da Coruña, Donostiako Unibertsitate Ospitalea, Instituto de Investigación Sanitaria de Santiago, Complejo Hospitalario Torrecárdenas, University Hospital Complex Of Vigo, Hospital de Sant Pau, Hospital Clínico Universitario de Valladolid, Hospital San Pedro de Alcántara, Hospital Universitario 12 De Octubre
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,400
OpenAlex ID: W7160440206
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