Work

Efficacy and Safety of a Dual‐Wavelength 589/1319 nm Laser for the Treatment of Acne Erythema: A Split‐Face Randomized Controlled Trial

Year: 2026

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: ABSTRACT Background The 589/1319 nm solid‐state dual‐wavelength (SSDW) laser, which targets cutaneous vasculature, may be an effective treatment for acne erythema (AE). Objectives To compare the efficacy and safety of the 589/1319 nm SSDW laser with topical soothing Aloe vera (AV) gel for the treatment of AE. Patients and Methods Thirty patients with bilateral AE were enrolled. One facial side received 6 sessions of 589/1319 nm SSDW laser treatment, while the contralateral side was treated with twice‐daily AV gel for 18 weeks. Patients were followed for 8 weeks after the final laser session. AE severity, acne severity, and adverse events were assessed. Results Twenty‐nine patients completed the study. Both treatment modalities significantly reduced AE. The laser‐treated side demonstrated a faster clinical response, with a significant reduction compared to baseline at 2 weeks, whereas AV gel required 4 weeks to achieve a comparable effect (within‐group p < 0.05; no between‐group difference). At the 8‐week follow‐up, the response rate was 72% for the laser‐treated sides and 69% for the AV‐treated sides. AE improvement correlated with reductions in acne severity in the laser‐treated sides ( r s = 0.47, p = 0.03). Patients reported higher satisfaction with laser treatment up to 4 weeks after the final laser session. Average pain score for the laser treatment was 1.52 out of 10. No serious adverse events were observed. Conclusions The 589/1319 nm SSDW laser may be an effective early adjunctive treatment for acne erythema, offering minimal discomfort with no downtime and may additionally improve acne severity.

Source: Journal of Cosmetic Dermatology

DOI: 10.1111/jocd.70894