Work

Operative benefits of embolisation in advanced-stage juvenile nasopharyngeal angiofibroma: a meta-analytic comparison

Year: 2026

Type: article

Study designs: Systematic Review, Meta-Analysis

Abstract: Objectives Juvenile nasopharyngeal angiofibroma is a highly vascular benign tumour affecting adolescent males. Our aim was to compare operative outcomes in embolised and non-embolised patients, with emphasis on tumour stage. Methods A systematic review was conducted using three databases (PubMed, Scopus and Google Scholar) in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. Results Overall, 17 studies with a total of 524 patients met the inclusion criteria. The meta-analysis showed a significant difference in estimated blood loss between embolised and non-embolised groups (overall effect size -685 ml; p < 0.001). Additionally, embolised patients with advanced stage tumours tended to lose less blood during surgery than non-embolised patients (mean of 1551.9 ml vs. 4051.5 ml; p = 0.065). Conclusion This systematic review and meta-analysis demonstrate that pre-operative endovascular embolisation provides an operative advantage in patients undergoing juvenile nasopharyngeal angiofibroma surgical resection. A near-significant trend towards greater benefit in higher-stage tumours was observed ( p = 0.065), warranting further prospective investigation.

Source: The Journal of Laryngology & Otology

DOI: 10.1017/s0022215126104885

Authors: Aviv Yvonne Segal, Basem Hijazi, Ohad Ronen

Institutions: Bar-Ilan University, Western Galilee Hospital

Language: English

Topic: Head and Neck Surgical Oncology

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,550