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Genome-wide association study of conjugated pneumococcal vaccine antibody responses in South African infants

Year: 2026

Type: article

Study design: Observational Study

Abstract: Pneumococcal conjugate vaccines have substantially reduced global mortality, yet the genetic basis of vaccine-induced immunity is unclear. We analysed host genetic determinants of PCV7-induced IgG responses in 1017 South African infants. No genome-wide significant associations were identified, including at the HLA locus. In contrast to protein vaccines, where HLA strongly shapes responses, PCV7 responses appear less constrained by HLA-mediated antigen presentation. This reduced constraint could partially explain their consistent effectiveness across diverse populations.

Source: npj Vaccines

DOI: 10.1038/s41541-026-01585-8

Authors: Yong En Goh, Clare Cutland, Gaby Smits, Alexander T. Dilthey, James J. Gilchrist, Callum R. O’Neill, Fiona R. M. van der Klis, Manjinder S. Sandhu, Amanda Y. Chong, Shabir A. Madhi, Alexander J. Mentzer

Institutions: Centre for Human Genetics, Nanyang Technological University, University of Oxford, South African Medical Research Council, University of the Witwatersrand, National Institute for Public Health and the Environment, Düsseldorf University Hospital, Heinrich Heine University Düsseldorf, MRC Weatherall Institute of Molecular Medicine, Imperial College London

Language: English

Topic: Pneumonia and Respiratory Infections

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,890

Funders: Wellcome Trust, National Institute for Health and Care Research, Chinese Academy of Medical Sciences

Awards: G1139804978, The immunogenetics of humoral response, utilising COVID-19 as a model, The immunogenetics of humoral response, utilising COVID-19 as a model

OpenAlex ID: W7160465597

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