Work

Distinct supraspinal neural pathways underlie licking-induced alleviation of pain sensation and aversion in male mice

Year: 2026

Type: article

Abstract: ZI) neuronal ensembles are efferent to the hindlimb region of the primary somatosensory cortex (S1HL) and the ventral tegmental area (VTA), which regulate the sensory and affective components of licking-induced analgesia, respectively. These findings unveil critical cross-modal supraspinal pathways that enable tactile input to differentially regulate the sensory and affective components of nociception.

Source: Cell Reports

DOI: 10.1016/j.celrep.2026.117363

Authors: Hao-Di Tang, Hong-Bin Wang, Yuncheng Luo, Rong Luo, Jiao Jiao, Jia-Xin Yao, Fan Zhang, Li-Mei Yi, Xin Li, Fan Lei, Xia Zhang, Tao Zhu, Ruotian Jiang

Institutions: Sichuan University, West China Medical Center of Sichuan University, West China Hospital of Sichuan University

Language: English

Topic: Pain Mechanisms and Treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,620

Funders: National Natural Science Foundation of China, China Postdoctoral Science Foundation, Sichuan University, Sichuan Province Science and Technology Support Program, West China Hospital, Sichuan University

Awards: G2004952115, G3307589394, G452047747, G4885241546, G5957870240, G8156999616, G8639104925

OpenAlex ID: W7160503740

FWCI: 3.926

Cites: 48

Cited by: 1

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