Pomegranate juice consumption and lipid profile: An updated systematic review and meta-analysis.
Year: 2026
Type: review
Study designs: Systematic Review, Meta-Analysis
Abstract: Objective: Pomegranate juice (PJ) is rich in polyphenols with potential lipid-lowering effects. This study aimed to evaluate the impact of PJ consumption on blood lipid parameters through a systematic review and meta-analysis of randomized controlled trials (RCTs). Materials and Methods: A comprehensive literature search was conducted across multiple databases to identify RCTs assessing the effects of PJ on lipid profiles in adults. A total of 17 RCTs involving 663 participants were included. Outcomes analyzed were changes in total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). Subgroup and meta-regression analyses were performed based on dose, duration, and participant health status. Results: PJ consumption was associated with significant reductions in TG (MD: -8.2 mg/dL) and LDL-C (MD: -4.8 mg/dL), and a significant increase in HDL-C (MD: +2.8 mg/dL). No overall effect was observed for TC. High heterogeneity was detected, partially explained by differences in PJ dose and population characteristics. Conclusion: PJ may improve lipid profiles, particularly by reducing TG and LDL-C and increasing HDL-C levels. These effects appear more pronounced in populations with metabolic disorders. Future trials with standardized PJ formulations and longer durations are warranted.
Source: PubMed
Authors: Fatemeh Ghaemi, Maryam Emadzadeh, Wael Almahmeed, Tannaz Jamialahmadi, Sercan Karav, Amirhossein Sahebkar
Language: English
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7160517606
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