Work

Low-Energy Light-Driven Excited-State Palladium Catalysis: Cross-Coupling of Pyridine N -Oxides with Unactivated Alkyl Bromides

Year: 2026

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide Excited-state Pd catalysis has emerged as a new platform for cross-coupling reactions. Nonetheless, such catalysis typically requires high-energy near-ultraviolet (NUV) or blue (380–450 nm) light. In contrast, the use of lower-energy light (>520 nm) in excited-state Pd catalysis remains largely unexplored. Herein, we report a low-energy light-driven excited-state Pd-catalyzed cross-coupling of pyridine N -oxides with unactivated alkyl bromides. Mechanistic studies reveal the formation of a Pd(0)–pyridine N -oxide complex that absorbs low-energy light.

Source: Organic Letters

DOI: 10.1021/acs.orglett.6c01179

Authors: Jisun Kim, Minyoung Ju, Chaerin Baek, Eun Joo Roh, Jeongcheol Shin, Jung Tae Han

Institutions: KIST Medical College, Korea Institute of Science and Technology, Korea University of Science and Technology, Duksung Women's University

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500