Work

The Oxidative Stress: Origin and Role in Aging and Diseases

Year: 2026

Type: article

Abstract: Reactive oxygen species (ROS) play a dual role in biological systems: at low-to-moderate concentrations, they function as essential signaling molecules involved in processes such as cell proliferation, differentiation, and immune defense. However, excessive ROS production or impaired antioxidant defenses lead to oxidative stress, which can damage lipids, proteins, and DNA, contributing to the development and progression of various pathological conditions including cancer, cardiovascular diseases, neurodegenerative disorders, and aging. Understanding and managing oxidative stress is critical to promoting health and preventing chronic conditions. This review explores the growing body of literature surrounding this multifaceted and increasingly important area of study.

Source: Antioxidants

DOI: 10.3390/antiox15050597

Authors: Gabriella D’Orazi, Luca Neroni, Alessandra Verdina

Institutions: Saint Camillus International University of Health and Medical Sciences, Instituto Nazionale Tumori Regina Elena, San Gallicano Hospital, Istituti di Ricovero e Cura a Carattere Scientifico

Language: English

Topic: Antioxidant Activity and Oxidative Stress

Subfield: Biochemistry

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,499