Work

RNA-based therapeutics for Alzheimer’s disease and related tauopathies: challenges and opportunities

Year: 2026

Type: article

Abstract: Tauopathies are neurodegenerative diseases characterized by pathological tau protein accumulation. Though therapies involving monoclonal antibodies and small-molecule inhibitors have progressed, they have so far failed in multiple clinical trials, underscoring the need for innovative molecular approaches. RNA-based therapies offer an alternative disease-modifying approach by being able to target tau at its molecular origin. Diverse modalities, such as mRNA, ASO, RNAi, and SSO, offer distinct promises. Though their challenges are equally diverse, they also share common problems. This review examines the nascent field of RNA therapeutics for tauopathies, outlining emerging modalities, translational barriers, molecular targets, clinical trials, and patent trends.

Source: The Journal of Prevention of Alzheimer s Disease

DOI: 10.1016/j.tjpad.2026.100585

Authors: Binita Rajbanshi, Ilaria Brentari, Michela Alessandra Denti, Jeffrey L. Cummings, Anuj Guruacharya

Institutions: University of Trento, University of Nevada, Las Vegas

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,060