Unveiling the Role of Pseudomonas aeruginosa Quorum Sensing Inhibitors: The Road So Far
Year: 2026
Type: article
Abstract: ESKAPE bacteria represent a global threat to public health. These microorganisms employ a type of cell-cell communicationnamed "quorum sensing (QS) system," which involves the activation of specific signals to modulate drug resistance and pathogenic behaviors. Noteworthy, resistance of Pseudomonas aeruginosa to antibiotics is increasing, thus leading to a greater interest in the development of new antibacterial compounds by exploring valuable targets such as its complex QS system. This review intends to provide an extensive report about the advances in the identification of promising P. aeruginosa QS inhibitors as potential novel therapeutic options. This work represents a comprehensive analysis of research articles available on Pubmed, Scopus, and Google Scholar, from January 2020 to July 2025, referring to promising antivirulence compounds, affecting P. aeruginosa QS system.
Source: The Chemical Record
Authors: Valeria Tudino, Sara Rossi, Leonardo Milioni, Chiara Cosenza, Gabriele Carullo, Sandra Gemma, Stefania Butini, Giuseppe Campiani
Institutions: University of Siena, University of Pavia
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7160618242