Work

Base-Catalyzed Alcoholysis of N -Acylpyrrole-Type Amides Under Mild Conditions

Year: 2026

Type: article

Abstract: The cleavage of amide C-N bonds is of considerable interest across synthetic chemistry, biological processes, and the pharmaceutical industry. Conventionally, these transformations have necessitated the use of transition-metal catalysts or harsh reaction conditions, including strong acids, strong bases, and elevated temperatures. Here, a facile and practical method was reported for the alcoholysis of N-acylpyrrole-type amides under mild conditions using a weak base as the catalyst. This strategy offers a broad substrate scope and high functional group compatibility.

Source: ACS Omega

DOI: 10.1021/acsomega.6c02190

Authors: Peng-Fei Yang, Man-Li Feng, Li Li, Ge-Yan Huang, Yu-Ting Ma, Xiu-Li Zhang

Institutions: Bengbu University, Bengbu Medical College

Language: English

Topic: Advanced Synthetic Organic Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,935

Funders: Bengbu University, Natural Science Foundation of Anhui Province, Excellent Young Talents Fund Program of Higher Education Institutions of Anhui Province, National College Students Innovation and Entrepreneurship Training Program