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Synthesis and Reactivity of 3‐Aminosydnones in Cycloaddition Reactions With Alkynes

Year: 2026

Type: article

Abstract: We present in this article the synthesis, functionalization, and properties of 3-aminosydnones, a forgotten class of mesoionic compounds. Their capacity to react as 1,3-dipoles in cycloaddition reactions with cyclic alkynes was investigated, revealing their potential as valuable tools for bioconjugation applications.

Source: Chemistry - A European Journal

DOI: 10.1002/chem.71110

Authors: Apolline Dominic, Timothée D'anfray, Guillaume Force, David‐Alexandre Buisson, Maxime Tricoire, Alexis Leblais, Davide Audisio, Frédéric Taran

Institutions: Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Université Paris-Saclay, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Médicaments et Technologies pour la Santé, Centre National de la Recherche Scientifique, CEA Paris-Saclay - Etablissement de Saclay

Language: English

Topic: Organic Chemistry Cycloaddition Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,640

Funders: California Earthquake Authority, Agence Nationale de la Recherche

Awards: Sydnones Derivatives as Bioorthogonal Caged Electrophiles for Permanent Fluorescent Labelling, G7080048889

OpenAlex ID: W7160656704

FWCI:

Cites: 13

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